SynVet-50®

Intra-articular Injection for horses

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Quality

Affordable and User Friendly

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Unsurpassed purity in a synthetic, high molecular weight hyaluronic acid

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SynVet-50 uses non latex stoppers and plungers to reduce risk in latex sensitive patients

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Convenient to use, pre loaded 5 ml sterile glass syringe containing 2.5 ml SynVet-50

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Designed by a Veterinarian for Veterinarians

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SynVet-50 2.5 ml 20 mg/ml 50 mg

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3 year shelf life at room temperature.

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Frosted tip on the Glass syringe to ensure
a perfect seal when using poly hub needles.

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Highest molecular weight of any
synthetic HA at > 1.5 Mio Daltons.

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Highest concentration of
HA per ml at 20 mg/ml

Weight

Molecular Weight

Hyaluronan (HA) is present within articular cartilage where it is synthesised by chondrocytes and in synovial fluid where it is synthesised by type B synoviocytes.  Hyaluronan can exist as Hyaluronic acid, sodium hyaluronate or as hyaluronate depending on the environment in which it is found, and all terms are used interchangeably.  It has been recognised for many years and in several species that in osteoarthritis (OA) the molecular weight and concentration of HA were diminished by one-half to one-third of their normal values, giving rise to the concept of visco-supplementation.

The functional mechanisms of HA are directly dependent on the molecular weight and concentration of HA.  This concept should be kept in mind when choosing from the assorted preparations of HA available for use.  The molecular weight of equine synovial fluid HA has been reported to range between 2-3 million Daltons, while the reported concentration of HA ranges between 0.33 and 1.5mg/ml.  For the available HA products, molecular weight and price are typically directly and positively correlated.  Therefore, the high molecular weight preparations are recommended due to their increased efficacy and longer duration of action.

Hyaluronan imparts the viscoelastic nature to synovial fluid, which means it behaves as a viscous solution at low sheer rates and is elastic in nature at high sheer rates.  In synovial fluid HA also lubricates the synovial membrane/cartilage interface (boundary lubrication) and physically excludes active inflammatory components and leucocytes from the joint cavity, a mechanism known as steric exclusion.  Hyaluronan has additional direct anti-inflammatory effects and has been shown to decrease fibroblastic pannus formation in osteoarthritic joints.

The dosing routing for hyaluronan in horses has been arrived at based on clinical impressions, and there is wide variation in how horses respond clinically to HA administration.  When administered for idiopathic synovitis, HA would typically be injected intra-articularly (i.a.) every week  for 4 injections.  There is no rest period required after HA administration.  The manufacturer recommended doses are based on use in a fetlock or carpus, so when using HA in a large joint such as a stifle, one should probably administer a double dose.

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Compare Products sold in USA

How Supplied

Concentration

Avg. Molecular Weight

Equimed USA - SynVet-50

2.5 ml in 5 ml syringe

per ml

20 mg

per unit

50 mg

1.5 million dalton

Equimed USA - Gel-50

10 ml vial

per ml

5 mg

per unit

50 mg

1.3 million dalton

Equimed USA - Gel50

2.5 ml in 5 ml syringe

per ml

20 mg

per unit

50 mg

1.3 million dalton

Neogen - HyCoat

6 ml vial

per ml

5 mg

per unit

30 mg

750,000 dalton

Neogen - HyCoat

10 ml vial

per ml

5 mg

per unit

50 mg

750,000 dalton

Dechra Pharma Inc.- Hy-50

3 ml syringe

per ml

17 mg

per unit

50 mg

750,000 dalton

Bioniche- Map 5

2 ml vial

per ml

10 mg

per unit

20 mg

600,000 dalton

Bioniche- Map 5

10 ml vial

per ml

5 mg

per unit

50 mg

600,000 dalton

Kinetic Tech. - Hytryl

6 ml vial

per ml

10 mg

per unit

60 mg

600,000 dalton

Bayer. - Legend

4 ml vial

per ml

10 mg

per unit

40 mg

300,000 - 500,000 dalton

Bayer. - Legend

2 ml vial

per ml

10 mg

per unit

20 mg

300,000 - 500,000 dalton

Derived from Natural Sources (Rooster Comb)

Pharmacia. - Hylartin V

2 ml syringe

per ml

10 mg

per unit

20 mg

3 million dalton

Boehinger-Ingelheim - Hyvisc

2 ml syringe

per ml

11 mg

per unit

22 mg

1.5 million dalton

Fort Dodge - Hyalovet

2 ml syringe

per ml

10 mg

per unit

20 mg

500,000 - 700,000 dalton

Boehinger-Ingelheim. - Hyalovet

2 ml vial

per ml

10 mg

per unit

20 mg

500,000 - 700,000 dalton

Compare Products sold in USA

How Supplied

Concentration

Avg. Molecular Weight

Equimed USA - SynVet-50

2.5 ml in 5 ml syringe

per ml

20 mg

per unit

50 mg

1.5 million dalton

Equimed USA - Gel-50

10 ml vial

per ml

5 mg

per unit

50 mg

1.3 million dalton

Equimed USA - Gel50

2.5 ml in 5 ml syringe

per ml

20 mg

per unit

50 mg

1.3 million dalton

Neogen - HyCoat

6 ml vial

per ml

5 mg

per unit

30 mg

750,000 dalton

Neogen - HyCoat

10 ml vial

per ml

5 mg

per unit

50 mg

750,000 dalton

Dechra Pharma Inc.- Hy-50

3 ml syringe

per ml

17 mg

per unit

50 mg

750,000 dalton

Bioniche- Map 5

2 ml vial

per ml

10 mg

per unit

20 mg

600,000 dalton

Bioniche- Map 5

10 ml vial

per ml

5 mg

per unit

50 mg

600,000 dalton

Kinetic Tech. - Hytryl

6 ml vial

per ml

6 mg

per unit

60 mg

600,000 dalton

Bayer. - Legend

4 ml vial

per ml

10 mg

per unit

40 mg

300,000 - 500,000 dalton

Bayer. - Legend

2 ml vial

per ml

10 mg

per unit

20 mg

300,000 - 500,000 dalton

Derived from Natural Sources (Rooster Comb)

Pharmacia. - Hylartin V

2 ml syringe

per ml

10 mg

per unit

20 mg

3 million dalton

Boehinger-Ingelheim - Hyvisc

2 ml syringe

per ml

11 mg

per unit

22 mg

1.5 million dalton

Fort Dodge - Hyalovet

2 ml syringe

per ml

10 mg

per unit

20 mg

500,000 - 700,000 dalton

Boehinger-Ingelheim. - Hyalovet

2 ml vial

per ml

10 mg

per unit

20 mg

500,000 - 700,000 dalton

Weight

Molecular Weight

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