Intra-articular Injection for horses
Quality
Unsurpassed purity in a synthetic, high molecular weight hyaluronic acid
SynVet-50 uses non latex stoppers and plungers to reduce risk in latex sensitive patients
Convenient to use, pre loaded 5 ml sterile glass syringe containing 2.5 ml SynVet-50
Designed by a Veterinarian for Veterinarians
SynVet-50 2.5 ml 20 mg/ml 50 mg
3 year shelf life at room temperature.
Frosted tip on the Glass syringe to ensure
a perfect seal when using poly hub needles.
Highest molecular weight of any
synthetic HA at > 1.5 Mio Daltons.
Highest concentration of
HA per ml at 20 mg/ml
Weight
Hyaluronan (HA) is present within articular cartilage where it is synthesised by chondrocytes and in synovial fluid where it is synthesised by type B synoviocytes. Hyaluronan can exist as Hyaluronic acid, sodium hyaluronate or as hyaluronate depending on the environment in which it is found, and all terms are used interchangeably. It has been recognised for many years and in several species that in osteoarthritis (OA) the molecular weight and concentration of HA were diminished by one-half to one-third of their normal values, giving rise to the concept of visco-supplementation.
The functional mechanisms of HA are directly dependent on the molecular weight and concentration of HA. This concept should be kept in mind when choosing from the assorted preparations of HA available for use. The molecular weight of equine synovial fluid HA has been reported to range between 2-3 million Daltons, while the reported concentration of HA ranges between 0.33 and 1.5mg/ml. For the available HA products, molecular weight and price are typically directly and positively correlated. Therefore, the high molecular weight preparations are recommended due to their increased efficacy and longer duration of action.
Hyaluronan imparts the viscoelastic nature to synovial fluid, which means it behaves as a viscous solution at low sheer rates and is elastic in nature at high sheer rates. In synovial fluid HA also lubricates the synovial membrane/cartilage interface (boundary lubrication) and physically excludes active inflammatory components and leucocytes from the joint cavity, a mechanism known as steric exclusion. Hyaluronan has additional direct anti-inflammatory effects and has been shown to decrease fibroblastic pannus formation in osteoarthritic joints.
The dosing routing for hyaluronan in horses has been arrived at based on clinical impressions, and there is wide variation in how horses respond clinically to HA administration. When administered for idiopathic synovitis, HA would typically be injected intra-articularly (i.a.) every week for 4 injections. There is no rest period required after HA administration. The manufacturer recommended doses are based on use in a fetlock or carpus, so when using HA in a large joint such as a stifle, one should probably administer a double dose.
compare
Equimed USA - SynVet-50
2.5 ml in 5 ml syringe
per ml
20 mg
per unit
50 mg
1.5 million dalton
Equimed USA - Gel-50
10 ml vial
per ml
5 mg
per unit
50 mg
1.3 million dalton
Equimed USA - Gel50
2.5 ml in 5 ml syringe
per ml
20 mg
per unit
50 mg
1.3 million dalton
Neogen - HyCoat
6 ml vial
per ml
5 mg
per unit
30 mg
750,000 dalton
Neogen - HyCoat
10 ml vial
per ml
5 mg
per unit
50 mg
750,000 dalton
Dechra Pharma Inc.- Hy-50
3 ml syringe
per ml
17 mg
per unit
50 mg
750,000 dalton
Bioniche- Map 5
2 ml vial
per ml
10 mg
per unit
20 mg
600,000 dalton
Bioniche- Map 5
10 ml vial
per ml
5 mg
per unit
50 mg
600,000 dalton
Kinetic Tech. - Hytryl
6 ml vial
per ml
10 mg
per unit
60 mg
600,000 dalton
Bayer. - Legend
4 ml vial
per ml
10 mg
per unit
40 mg
300,000 - 500,000 dalton
Bayer. - Legend
2 ml vial
per ml
10 mg
per unit
20 mg
300,000 - 500,000 dalton
Pharmacia. - Hylartin V
2 ml syringe
per ml
10 mg
per unit
20 mg
3 million dalton
Boehinger-Ingelheim - Hyvisc
2 ml syringe
per ml
11 mg
per unit
22 mg
1.5 million dalton
Fort Dodge - Hyalovet
2 ml syringe
per ml
10 mg
per unit
20 mg
500,000 - 700,000 dalton
Boehinger-Ingelheim. - Hyalovet
2 ml vial
per ml
10 mg
per unit
20 mg
500,000 - 700,000 dalton
Equimed USA - SynVet-50
2.5 ml in 5 ml syringe
per ml
20 mg
per unit
50 mg
1.5 million dalton
Equimed USA - Gel-50
10 ml vial
per ml
5 mg
per unit
50 mg
1.3 million dalton
Equimed USA - Gel50
2.5 ml in 5 ml syringe
per ml
20 mg
per unit
50 mg
1.3 million dalton
Neogen - HyCoat
6 ml vial
per ml
5 mg
per unit
30 mg
750,000 dalton
Neogen - HyCoat
10 ml vial
per ml
5 mg
per unit
50 mg
750,000 dalton
Dechra Pharma Inc.- Hy-50
3 ml syringe
per ml
17 mg
per unit
50 mg
750,000 dalton
Bioniche- Map 5
2 ml vial
per ml
10 mg
per unit
20 mg
600,000 dalton
Bioniche- Map 5
10 ml vial
per ml
5 mg
per unit
50 mg
600,000 dalton
Kinetic Tech. - Hytryl
6 ml vial
per ml
6 mg
per unit
60 mg
600,000 dalton
Bayer. - Legend
4 ml vial
per ml
10 mg
per unit
40 mg
300,000 - 500,000 dalton
Bayer. - Legend
2 ml vial
per ml
10 mg
per unit
20 mg
300,000 - 500,000 dalton
Pharmacia. - Hylartin V
2 ml syringe
per ml
10 mg
per unit
20 mg
3 million dalton
Boehinger-Ingelheim - Hyvisc
2 ml syringe
per ml
11 mg
per unit
22 mg
1.5 million dalton
Fort Dodge - Hyalovet
2 ml syringe
per ml
10 mg
per unit
20 mg
500,000 - 700,000 dalton
Boehinger-Ingelheim. - Hyalovet
2 ml vial
per ml
10 mg
per unit
20 mg
500,000 - 700,000 dalton
Weight
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